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The cardiovascular system is made up of the heart (a muscular pump), the veins (vessels leading toward the heart), and the arteries (vessels leading away from the heart). Valves in the heart keep blood flowing in one direction. The nervous system and several hormones control heart rate, blood pressure, and strength of contractions of the heart. Nearly 10 percent of all domestic animals have some kind of disease involving the cardiovascular system. Unlike most diseases, heart diseases can rarely be resolve, and instead get slowly worse. Untreated, these diseases become more and more limiting and may eventually lead to death. Modern advances in veterinary medicine have allowed the treatment of many cardiac conditions with great variety of drugs. This article aims to help you understand the rationale behind some of the more common drugs prescribed for pets with heart conditions. These drugs may be used by themselves or in combination, depending on diagnosis and severity of disease. In addition, other drugs, such as diuretics and bronchodilators may be used to reduce symptoms associated with some heart conditions. Digitalis glycosides, DigitalinsGeneric Names: Digitoxin, DigoxinTrade Names: Foxaline, Cardoxin, LanoxinDigitalis glycosides are derived from the foxglove plant and act to increase the force of the heart's contractions, expelling more blood per heartbeat. In addition, digitalins decrease heart rate. Digitalins are most commonly used to treat congestive heart failure, dilated cardiomyopathy of dogs, and disturbances causing rapid heart rates. Therapy with digitalis glycosides must be carefully monitored for signs of digitalis toxicity, which include weakness, lethargy, anorexia, vomiting, diarrhea, and abnormally slow heart rates.Antihypertensive drugs, High Blood Pressure drugsGeneric Names: Captopril, Enalapril, Verapamil, Diltiazem, Hydralazine, NitroglycerineTrade Names: Capoten, Enacard, Calan, Isoptin, Dilacor, Apresoline, Nitrostat Vasodilators fall into many classes, but all act to dilate arteries (arteriodilators) and/or veins (venodilators). Arteriodilators, such as hydralazine, decrease resistance in the arteries, making it easier for the heart to pump blood forward. Arteriodilators are sometimes used to reduce symptoms associated with mitral valve disease. Venodilators, like nitroglycerine, helps prevent blood from "backing up" behind a sick heart and reduces signs of congestive heart failure, such as breathing difficulties caused by pulmonary edema ("water on the lungs"). The ACE Inhibitors enalapril and captopril dilate both arteries and veins, but their major contribution is in reducing high blood pressure by interfering with the hormones responsible for water and salt retention. In general, vasodilator drugs are used to treat a variety of diseases, including cardiomyopathy and valvular diseases. Beta Blockers, Beta Adrenergic Blocking DrugsGeneric Names: PropanololTrade Names: Inderal Beta-blockers slow the heart rate, giving the muscular ventricles more time to relax and fill with blood between each successive contraction. In doing so, beta-blockers allow the heart to be more efficient, pumping more blood with every stroke. This class of drugs may be used to treat a variety of disturbances in heart rate and rhythm, as well as high blood pressure, dilated cardiomyopathy (dogs) and hypertrophic cardiomyopathy (cats). Calcium Channel BlockersGeneric Names: Verapamil, DiltiazemTrade Names: Isoptin, Dilacor In addition to their use as vasodilators, calcium channel blockers also serve to slow heart rate and allow the ventricle to relax and fill. Diltiazem is commonly used in the treatment of hypertrophic cardiomyopathy in cats.
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